Molecular and biochemical principles of tumor enzyme therapy

   
Berezov  T.T.1

1. Department of Biochemistry Russian Peoples` Friendship University
Section: From the Editors
PubMed Id: 16104387
Year: 2005  Volume: 51  Issue: 3  Pages: 235-247
Bacterial enzymes are antineoplastic perspective agents in oncology. Current strategy of tumor enzyme therapy is primariy based on the strictly defined differences of biochemical properties between normal and tumor cells and more precisely on their different sensitivity to deficit of essential growth factors, including amino acids. The growth inhibitory effects of these bacteria enzymes: glutamine (asparagin)ase, methionine γ-lyase and lysine α-oxidase were demonstrated in in virto and in vivo using several tumor lines. These results suggest that commercial production of certified standard enzyme preparations and their knowledge-based rational application will provide a new potent anti-tumor preparations employed in oncology.
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Berezov T.T. (2005) Biomeditsinskaya khimiya, 51(3), 235-247.
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