Concentrations of extracellular deoxy- and ribonucleic acids in blood plasma and cell-surface-bound of blood cells were investigated in healthy donors and patients with malignant gastrointestinal tumor. Our results indicate that high concentration of extracellular DNA in blood plasma along with decreased level of extracellular RNA on the surface of blood cells correlate with development of gastrointestinal cancer. Ratio of nucleic acids in plasma to total amount of nucleic acids circulated in blood is a characteristic parameter distinguishing cancer patients healthy persons.
Tamkovich S.N. et al. Circulating nucleic acids in blood of patients with malignant tumors of gastrointestinal tract // Biomeditsinskaya khimiya. - 2005. - V. 51. -N 3. - P. 321-328.
Tamkovich S.N. et al., "Circulating nucleic acids in blood of patients with malignant tumors of gastrointestinal tract." Biomeditsinskaya khimiya 51.3 (2005): 321-328.
Tamkovich, S. N., Bryzgunova, O. E., Rykova, E. Yu., Kolesnikova, E. V., Shelestuk, P. I., Laktionov, P. P., Vlassov, V. V. (2005). Circulating nucleic acids in blood of patients with malignant tumors of gastrointestinal tract. Biomeditsinskaya khimiya, 51(3), 321-328.