Circulating nucleic acids in blood of patients with malignant tumors of gastrointestinal tract

   
Tamkovich S.N.1, Bryzgunova O.E.1, Rykova E.Yu.1, Kolesnikova E.V.2, Shelestuk P.I.2, Laktionov P.P.1, Vlassov V.V.1

1. Institute of chemical Biology and Fundamental Medicine SB of RAS
2. Novosibirsk Oncological Dispensary
Section: Experimental/Clinical Study
PubMed Id: 16104395
Year: 2005  Volume: 51  Issue: 3  Pages: 321-328
Concentrations of extracellular deoxy- and ribonucleic acids in blood plasma and cell-surface-bound of blood cells were investigated in healthy donors and patients with malignant gastrointestinal tumor. Our results indicate that high concentration of extracellular DNA in blood plasma along with decreased level of extracellular RNA on the surface of blood cells correlate with development of gastrointestinal cancer. Ratio of nucleic acids in plasma to total amount of nucleic acids circulated in blood is a characteristic parameter distinguishing cancer patients healthy persons.
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Keywords: blood plasma, blood cells, extracellular nucleic acids, cell-surface-bound nucleic acids, stomach cancer, colorectal cancer
Citation:

Tamkovich, S. N., Bryzgunova, O. E., Rykova, E. Yu., Kolesnikova, E. V., Shelestuk, P. I., Laktionov, P. P., Vlassov, V. V. (2005). Circulating nucleic acids in blood of patients with malignant tumors of gastrointestinal tract. Biomeditsinskaya khimiya, 51(3), 321-328.
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