There is evidence that cells respond not only to biologically active substances, but also to external mechanical effects. This is especially important for cellular elements of vascular walls and blood. Mechanical treatment cause so-called stretch-deformation of plasma membranes and forces generated by shift of plasma layers induce shear stress. Good experimental evidence exists that mechanical effects influence functional activity of vascular wall and blood cells.
Download PDF:
Keywords: membranes, shear stress
Citation:
Glushkov V.S., Storozhok S.A., Panchenko L.F., Silina E.G. (2005) Role of membrane deformations in regulation of functions of cells. Biomeditsinskaya Khimiya, 51(5), 473-480.
Glushkov V.S. et al. Role of membrane deformations in regulation of functions of cells // Biomeditsinskaya Khimiya. - 2005. - V. 51. -N 5. - P. 473-480.
Glushkov V.S. et al., "Role of membrane deformations in regulation of functions of cells." Biomeditsinskaya Khimiya 51.5 (2005): 473-480.
Glushkov, V. S., Storozhok, S. A., Panchenko, L. F., Silina, E. G. (2005). Role of membrane deformations in regulation of functions of cells. Biomeditsinskaya Khimiya, 51(5), 473-480.
Zamir E., Katz B.Z., Aota S., Yamada K.M., Geiger B., Kam Z. (1999) J. Cell Sci., 112, 1655-1669. Scholar google search
YoganathanT.N., CostelloP., ChenX., Jabali M., Yan J., LeungD., Zhang Z., Yee A., Dedhar S., Sanghera J. (2000) Biochem. Pharmacol., 60, 1115-1119. Scholar google search
OgasawaraM., Kim S.C., Adamik R., TogawaA., Ferrans V.J., TakedaK., Kirby M., Moss J., Vaughan M. (2000) J. Biol. Chem., 275, 3221-3230. Scholar google search
Geiger C., Nagel W., Boehm T., van Kooyk Y., Figdor C.G., KremmerE., Hogg N., Zetlmann L., Dierks H., Weber K.S.C., KolanusW. (2000) EMBO J., 19, 2525-2536. Scholar google search
Moazzam F., DeLano F.A., Zweifach B. W., Schmid-Schonbein G.W. (1997) Proc. Natl. Acad. Sci. USA, 94, 5338-5343. Scholar google search
