Lysosomal cyteine proteinases at neoplastic transformation

   
Dilakyan E. A.1, Tsvetkova I.V.1

1. Institute of Biomedical Chemistry RAMS
Section: Review
UDK:       PubMed Id: 16342665
Year: 2005  Volume: 51  Issue: 5  Pages: 485-500
This review summarizes the data on classification, properties, structure and biological functions of mammalian papain-like lysosomal cysteine proteinases (cathepsins). The most studied are cathepsins B, H, L, S and K. Yhe peculiarities of lysosomal cysteine proteinases regulation, particularly regulation by specific endorgenous inhibitors are discussed. Involvement of these enzymes in development of physiological and pathological processes are considered. Special attention is paid to the role of cysteine proteinases and their inhibitors in neoplastic transformation. The possibility of use cathepsin endogenous inhibitors as basis for design antitumorogenic therapeutic substances are discussed.
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Dilakyan E. A., Tsvetkova I.V. (2005) Biomeditsinskaya khimiya, 51(5), 485-500.
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