The effect of asian cobra venom on the content of rat heart and liver mitochondrial phospholipids and the protective effect of benzonal

   
Shirinova I.A.1, Nurdinov Sh.Sh.1, Klemesheva L.S.1, Almatov  K.T.1

1. M. Ulugbek National University of Uzbekistan
Section: Experimental/Clinical Study
PubMed Id: 16342667
Year: 2005  Volume: 51  Issue: 5  Pages: 513-518
Administration of a cobra venom to rats resulted in decrease of heart and liver mitochondrial cardiolipins (1.88 and 1.29 times), phosphatidylethanolamines (1.56 and 1.42 times) and phosphatidic acid (1.14 and 1.29 times), whereas the content of phosphadtidylcholins increased by 1.42 and 1.51-fold, respectively. The content of phosphadtidylinositol increased by 3.09 times in liver mitochondria and decreased by 1.28 times in heart mitochondrial phosphadtidylserine content impaired after the venom administration but even exceeded it. Benzonal also minimized changes in mitochondrial phospholipid induced by the cobra venom, and also reduced liver and heart phosphatidic acid content by 1.36 and 1.7 times
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Keywords: rats, liver, heart, mitochondria, phospholipids, snake venom, Central Asian cobra Naja naja oxiana Echwald, benzonal
Citation:

Shirinova, I. A., Nurdinov, Sh. Sh., Klemesheva, L. S., Almatov, , K. T. (2005). The effect of asian cobra venom on the content of rat heart and liver mitochondrial phospholipids and the protective effect of benzonal. Biomeditsinskaya Khimiya, 51(5), 513-518.
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