Elevated plasma homocysteine and glutathione level in patients with renal failure

Golubev R.V.1, Blashko E.L.2, Dobronravov V.A.1, Zhloba A.A.2 , Smirnov A.V.1

1. Nephrology Research Institute
2. SC Department of Biochemistry, St.-Petersburg State I. P. Pavlov Medical University
Section: Short Communication
PubMed Id: 16342673
Year: 2005  Volume: 51  Issue: 5  Pages: 549-551
The levels of homocysteine (Hcy) and glutatione (Glt) were determined in plasma of 219 patients with different stages of chronic kidney disease (CKD) (94 patients recieved chronic bicarbonate hemodialysis and 125 patients were at predialysis stage). The elevated Hcy level was detected in an early stage of CKD and reached maximal values and spreading in the hemodialysis patients. The levels of total and reduced Hcy (tHcy and rHcy, respectively) were also higher in CKD patients: the proportion of rHcy in total pool of plasma Hcy was significally higher than in healthy subjects. In the group of non-dialysed patients the reverse dependence between glomerular filtration rate (GFR) value and Hcy plasma concentration was found. We did not find any correlation between Glt and GFR in predialysis patients, but there was direct dependence between Glt and tHcy plasma levels in this group. Glt plasma levels in dialysis patients were reliably lower than in predialysis ones. There was a lack of some correlation between Glt and tHcy in the haemodialysis group.
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Keywords: haemodialysis, glutathione, homocysteine

Golubev, R. V., Blashko, E. L., Dobronravov, V. A., Zhloba, A. A., Smirnov, A. V. (2005). Elevated plasma homocysteine and glutathione level in patients with renal failure. Biomeditsinskaya Khimiya, 51(5), 549-551.
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