The effects of L-arginine and inhibitors of NO-synthase on the level of stable NO metabolites and nitrosothiols have been investigated under conditions of toxic damage of liver induced by CCI4. The L-arginine improved resistance of hepatic cells to damaging action of tetrachloromethane, but inhibition of NO-synthase increased hepatotropic action of CCI4. The existence of some base level of nitrosothiols, acting as a reserve pool of nitric oxide in organism, has been supposed
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Keywords: toxic damage of liver, nitric oxide, nitrosothiols
Citation:
Bliznetsova G.N., Artemieva S.S., Retsky M.M. (2005) Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver. Biomeditsinskaya Khimiya, 51(6), 656-661.
Bliznetsova G.N. et al. Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver // Biomeditsinskaya Khimiya. - 2005. - V. 51. -N 6. - P. 656-661.
Bliznetsova G.N. et al., "Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver." Biomeditsinskaya Khimiya 51.6 (2005): 656-661.
Bliznetsova, G. N., Artemieva, S. S., Retsky, , M. M. (2005). Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver. Biomeditsinskaya Khimiya, 51(6), 656-661.
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