Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver

   
Bliznetsova G.N.1, Artemieva S.S.1, Retsky  M.M.1

1. Voronezh State University
Section: Experimental/Clinical Study
PubMed Id: 16521828
Year: 2005  Volume: 51  Issue: 6  Pages: 656-661
The effects of L-arginine and inhibitors of NO-synthase on the level of stable NO metabolites and nitrosothiols have been investigated under conditions of toxic damage of liver induced by CCI4. The L-arginine improved resistance of hepatic cells to damaging action of tetrachloromethane, but inhibition of NO-synthase increased hepatotropic action of CCI4. The existence of some base level of nitrosothiols, acting as a reserve pool of nitric oxide in organism, has been supposed
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Keywords: toxic damage of liver, nitric oxide, nitrosothiols
Citation:

Bliznetsova, G. N., Artemieva, S. S., Retsky, , M. M. (2005). Influence of L-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver. Biomeditsinskaya khimiya, 51(6), 656-661.
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