Analysis of contact interfaces of HIV reverse transcriptase subunits

Belov D.A.1, Veselovsky A.V.1

1. Institute of Biomedical Chemistry RAMN
Section: Experimental/Clinical Study
UDK: 577.152.3     
Year: 2006  Volume: 52  Issue: 1  Pages: 19-28
Analysis of structure and features of subunit contact areas of reverse transcriptase (RT) HIV was done. The amino acid residues from contact areas of RT subunits are more conservative than the rest residues of the protein. Estimation of contribution of the amino acid residues from contact areas in binding energy of subunits showed that binding energy is mostly localized on the several amino acid residues of the dimer interface (hot spots). The majority of these hot spots form several clusters on contact surfaces. Analysis of these clusters allows to predict the region on the contact area of protein dimer that can be useful for design the inhibitors of dimerization of RT HIV.
Download PDF:

Belov D.A., Veselovsky A.V. (2006) Biomeditsinskaya khimiya, 52(1), 19-28.
This paper is also available as the English translation:10.1134/S1990750807010027
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)

© Institute of Biomedical Chemistry, Moscow, Russia