Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases
Newly synthesized compounds, namely, platinum and palladium metal complexes based on substituted pyridinecarboxylic acids inhibit both active transport of Ca ions and hydrolysis of ATP, catalyzed by sarcoplasmic reticulum Са2+-ATPase.The degree of active transport of Ca ions to vesicles correlated to the inhibition of metastases of experimental melanoma B16 by compounds studied. We suggest that the mechanism responsible for inhibition of metastases by newly synthesized compounds consists in change of normal ratio of extra- and intracellular content of Ca2+ ions that influences platelet aggregation, required for adhesion of metastasizing tumor cells to vascular walls.
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Keywords: Ca2+-ATPase, sarcoplasmic reticulum, nicotinamides, isonicotinamides, metal complexes, antimetastatic activity
Citation:
Tatyanenko L.V., Konovalova N.P., Bogdanov G.N., Dobrokhotova O.V., Fedorov B.S. (2006) Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases. Biomeditsinskaya Khimiya, 52(1), 52-59.
Tatyanenko L.V. et al. Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases // Biomeditsinskaya Khimiya. - 2006. - V. 52. -N 1. - P. 52-59.
Tatyanenko L.V. et al., "Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases." Biomeditsinskaya Khimiya 52.1 (2006): 52-59.
Tatyanenko, L. V., Konovalova, N. P., Bogdanov, G. N., Dobrokhotova, O. V., Fedorov, B. S. (2006). Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases. Biomeditsinskaya Khimiya, 52(1), 52-59.
