Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases

   
Tatyanenko L.V.1, Konovalova N.P.1, Bogdanov G.N.1, Dobrokhotova O.V.1, Fedorov B.S.1

1. Institute of Problems of Chemical Physics, RAS
Section: Experimental/Clinical Study
PubMed Id: 16739921
Year: 2006  Volume: 52  Issue: 1  Pages: 52-59
Newly synthesized compounds, namely, platinum and palladium metal complexes based on substituted pyridinecarboxylic acids inhibit both active transport of Ca ions and hydrolysis of ATP, catalyzed by sarcoplasmic reticulum Са2+-ATPase.The degree of active transport of Ca ions to vesicles correlated to the inhibition of metastases of experimental melanoma B16 by compounds studied. We suggest that the mechanism responsible for inhibition of metastases by newly synthesized compounds consists in change of normal ratio of extra- and intracellular content of Ca2+ ions that influences platelet aggregation, required for adhesion of metastasizing tumor cells to vascular walls.
Download PDF:
Keywords: Ca2+-ATPase, sarcoplasmic reticulum, nicotinamides, isonicotinamides, metal complexes, antimetastatic activity
Citation:

Tatyanenko, L. V., Konovalova, N. P., Bogdanov, G. N., Dobrokhotova, O. V., Fedorov, B. S. (2006). Inhibition of active transport of calcium ions by Pt(IV) and Pd(II) metal complexes. Correlation between the process and the inhibition of growth of experimental metastases. Biomeditsinskaya khimiya, 52(1), 52-59.
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)