Changes of the lipoprotein metabolism in alcohol dependence do not recover under conditions of prolonged remission

   
Bozhko G.Kh.1 , Sokolyk V.V.1, Chursina V.S.1, Artemchuk A.F.1

1. Institute of Neurology, Psychiatry and Narcology of the AMS of Ukraine
Section: Experimental/Clinical Study
UDK: 616.89-008.441.13-036.66:577.11      PubMed Id: 16805392
Year: 2006  Volume: 52  Issue: 2  Pages: 192-199
Сontents of lipoproteins (LP), activity of lipoprotein lipase (LP-lipase) and cholesterol esterification activity of blood serum were examined in patients with alcoholism at the periods of intoxication, alcohol abstinence and under conditions of prolonged remission. During remission a general pattern of apoB-containing LP was similar to the period of intoxication. Processes of transformation of this class LP significantly delayed in isolated blood serum in vitro. The magnitude of these changes almost corresponded to the period of intoxication. However activity of free and membrane-bound forms of LP-lipase. A high level of LPHD2a was characteristic for the conditions of intoxication and alcohol abstinence. In the remission the level of all the apoA-containing LP fractions was significantly lower than in the control. Besides, processes of their transformations in vitro were slowed down. Intensity of these changes resembled the period of intoxication.Thus, disorders of LP metabolism pointed out during the period of intoxication and alcohol abstinence do not recovered under conditions of a prolonged remission.
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Bozhko G.Kh., Sokolyk V.V., Chursina V.S., Artemchuk A.F. (2006) Biomeditsinskaya khimiya, 52(2), 192-199.
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