Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice

   
Kulinsky V.I.1 , Gavrilina T.V.1, Minakina L.N.2, Kovtun V.Yu.3

1. Department of Biochemistry, Irkutsk State Medical University
2. Department of Pharmacology, Irkutsk State Medical University
3. SPC Pharmprotection
Section: Experimental/Clinical Study
UDK: 577.17:615.21:616.831-005.4      PubMed Id: 16898589
Year: 2006  Volume: 52  Issue: 3  Pages: 309-316
Different types of hypoxic preconditioning (hypoxic, circulatory, hemic and tissue hypoxia) increase the tolerance to complete global cerebral ischemia at early terms (hours). Biochemico-pharmacological analysis with the use of selective agonists and antagonists showed the importance of adenosine A1-receptors and K+ATP-channels in the mechanisms of the neuroprotective effect and natural tolerance. The general scheme of the investigated mechanisms of different types of hypoxic preconditioning has been proposed.
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Kulinsky V.I., Gavrilina T.V., Minakina L.N., Kovtun V.Yu. (2006) Biomeditsinskaya khimiya, 52(3), 309-316.
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