Interrupted alcohol treatment and liver: free radicalhomeostasis, nitric oxide, adaptive mechanisms

Miskevich D.A.1 , Borodinsky A.N.1, Petushok N.E.1, Konovalenko O.V.1, Lelevich V.V.1

1. Department of Regulation of Metabolism, Institute of Biochemistry
Section: Experimental/Clinical Study
UDK: 615.015.6+613.83      PubMed Id: 17180923
Year: 2006  Volume: 52  Issue: 5  Pages: 489-495
Alcohol administration can result in liver damage. Reactive oxygen species (ROS), nitric oxide (NO) and their interaction are crucial factors in this process. The aim of work was to investigate free radical state and mechanisms of adaptation of the antioxidant system (AOS) to stress, caused by interrupted alcohol intake. Repeated cycles of alcoholization caused an imbalance between production and utilization of various ROS. This imbalance was due to impairments in thesystem superoxide dismutase/catalase. Nevertheless, in most experimental groups there was clear reduction of lipid peroxidation (LPO) products evaluated by thiobarbituric acid reactive substances. This might be attributed to the antioxidant effect of NO. However, there was an increased level of transaminases in blood plasma. After 28 days of this experimental scheme all the parameters studied normalized.
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Miskevich D.A., Borodinsky A.N., Petushok N.E., Konovalenko O.V., Lelevich V.V. (2006) Biomeditsinskaya khimiya, 52(5), 489-495.
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