А short test for potential carcinogenicity of water soluble synthetic polymers

Belokhvostova A.T.1 , Potapenkova L.S.1, Panarin E.F.2, Solovskij M.V.2, Ivanova N.P.2, Nazarova O.V.2, Gaurilova I.I.2, Jershov A. Ju.2

1. N.N. Petrov Oncology Research Institute of the Ministry of Health of the Russian Federation
2. Institute of Macromolecular Compounds, Russian Academy of Sciences
Section: Experimental/Clinical Study
PubMed Id: 17180924
Year: 2006  Volume: 52  Issue: 5  Pages: 495-506
The effect of synthetic water-soluble polymer with different structure on the appearance in SZNA mice of carcinogen-protein adducts (CPA) containing endogenous carcinogen, 3 - oxyanthranilic acid (3 - OAA), was investigated. CPA containing 3-OAA (3- OAA-CPA) were detected during the administratiоn of 24 of 30 investigated polymers. The induction of 3-OAA-CPA and the character of their distribution in the organism (in all investigated tissues: serum, extracts of liver, spleen, lungs and kidneys tissues or in single tissues) depended on the chemical structure of polymers. It is concluded, that synthetic polymers represent potential cancerogenic danger, because their administratiоn causes formation of 3-OAA-CPA in the organism of animals.
Download PDF:
Keywords: carcinogen-protein adducts, 3-oxyanthranilic acid, synthetic polymer, oncological risk, blood serum, tissue extracts

Belokhvostova, A. T., Potapenkova, L. S., Panarin, E. F., Solovskij, M. V., Ivanova, N. P., Nazarova, O. V., Gaurilova, I. I., Jershov, A. , Ju. (2006). А short test for potential carcinogenicity of water soluble synthetic polymers. Biomeditsinskaya khimiya, 52(5), 495-506.
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)