Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels
Kurhalyuk N.N.1 , Tkachenko G.M.2
1. Pomeranian Pedagogical University, Inst. Biology and Environmental Protection, Depart. Zoology and Animals Physiology 2. Danylo Galitski National Medical University of Lviv
The effects of the activator of ATP-sensitive potassium channels (KATP) pinacidil (0.06 mg/kg) and the blocker of these channels glibenclamide (1 mg/kg) were investigated using liver and heart mitоchondria isolated from rats exhibiting high (HR) or low-resistance (LR) to hypoxia. The animals were subjected to emotional stress. Stress caused activation of mitochondrial succinate oxidation, the decrease of efficiency of alpha-ketoglutarate oxidation and intensification of lipid peroxidation (LPO). These changes were more pronounced in the LR-animals. Administration of pinacidil protected mitochondria under conditions of stress, of whereas glibenclamide abolished these changes.
Kurhalyuk N.N., Tkachenko G.M. (2006) Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels. Biomeditsinskaya Khimiya, 52(6), 556-567.
Kurhalyuk N.N. et al. Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels // Biomeditsinskaya Khimiya. - 2006. - V. 52. -N 6. - P. 556-567.
Kurhalyuk N.N. et al., "Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels." Biomeditsinskaya Khimiya 52.6 (2006): 556-567.
Kurhalyuk, N. N., Tkachenko, G. M. (2006). Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels. Biomeditsinskaya Khimiya, 52(6), 556-567.
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