Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels

   
Kurhalyuk N.N.1 , Tkachenko G.M.2

1. Pomeranian Pedagogical University, Inst. Biology and Environmental Protection, Depart. Zoology and Animals Physiology
2. Danylo Galitski National Medical University of Lviv
Section: Experimental/Clinical Study
UDK: 612.3: 612.26: 612.814:612.015.3      PubMed Id: 17288247
Year: 2006  Volume: 52  Issue: 6  Pages: 556-567
The effects of the activator of ATP-sensitive potassium channels (KATP) pinacidil (0.06 mg/kg) and the blocker of these channels glibenclamide (1 mg/kg) were investigated using liver and heart mitоchondria isolated from rats exhibiting high (HR) or low-resistance (LR) to hypoxia. The animals were subjected to emotional stress. Stress caused activation of mitochondrial succinate oxidation, the decrease of efficiency of alpha-ketoglutarate oxidation and intensification of lipid peroxidation (LPO). These changes were more pronounced in the LR-animals. Administration of pinacidil protected mitochondria under conditions of stress, of whereas glibenclamide abolished these changes.
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Kurhalyuk N.N., Tkachenko G.M. (2006) Biomeditsinskaya khimiya, 52(6), 556-567.
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