The role of small molecules in regulation of activity of cytoplasmatic dehydrogenases

   
Gilmiyarova F.N.1 , Radomskaya V.M.1, Myakisheva Yu.V.1, Baisheva G.M.1, Pervova Yu.V.1, Spiridonova N.V.1

1. Samara State Medical University, Russian Ministry of Public Health, Department of Basic and Clinical Biochemistry with Laboratory Diagnostics
Section: Experimental/Clinical Study
UDK: 577.150.5      PubMed Id: 17288250
Year: 2006  Volume: 52  Issue: 6  Pages: 587-594
The influence of silistrong on the activity of erythrocyte cytoplasmatic dehydrogenases and also purified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was studied. Silistrong and its biologically active components (ethanol and silimarine) were found to activate GAPDH, lactate dehydrogenase (LDH), α-glycerophosphate dehydrogenase (GPDH) both in lysates of erythrocytes and in isolated GAPDH.The compounds studied are able to protect these enzymes and also to restore their activity of enzymes modified by hydrogen peroxide. Maximal activity is a characteristic of silistrong.
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Gilmiyarova F.N., Radomskaya V.M., Myakisheva Yu.V., Baisheva G.M., Pervova Yu.V., Spiridonova N.V. (2006) Biomeditsinskaya khimiya, 52(6), 587-594.
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