Changes of some energy exchange parameters in the rat heart under insulin hypoglycemia

   
Potapov P.P.1 , Stelmach A.Yu.1, Telushkin P.K.1, Medvedeva N.B.1

1. Yaroslavl State Medical Academy
Section: Short Communication
PubMed Id: 17288254
Year: 2006  Volume: 52  Issue: 6  Pages: 615-619
Hypoglycemic coma induced by administration of a large dose of insulin, was accompanied by the increased rates of glycolysis, glycogenolysis, activity of lactate dehydrogenase, succinate dehydrogenase, isocitrate dehydrogenase, and increased concentration of glycogen. Under these conditions triacylglycerol content decreased administration of the large dose of insulin to rats with alloxan diabetes increased not only rates of glycolysis, glycogenolysis and lactate dehydrogenase activity and also activities of aspartate transaminase and glutamate dehydrogenase. Data obtained suggest the increased utilization of amino acids for energy supply of myocardium under conditions of hypoglycemia induced by insulin adminisration to diabetic animals.
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Keywords: heart, insulin hypoglycemia, alloxan diabetes, glycolysis, energy metabolism, oxidative enzymes, aminotransferases
Citation:

Potapov, P. P., Stelmach, A. Yu., Telushkin, P. K., Medvedeva, N. B. (2006). Changes of some energy exchange parameters in the rat heart under insulin hypoglycemia. Biomeditsinskaya khimiya, 52(6), 615-619.
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