Penetration of ivermectin adsorbed on the surface of colloidal gold particles or included in micelles to phagocytic immune system cells was studied. Detection of the preparation in the cells was carried out by an immunochemical method, employing miniantibodies to ivermectin obtained from a combinatory phage library and by a chromatographic method on the HPLC system "Stayer". It was found that ivermectin adsorbed on colloidal gold particles was accumulated in the cells most intensively.
Pristensky D.V., Staroverov S.A., Ermilov D.N., Shchyogolev S.Yu., Dykman L.A. (2007) Analysis of effectiveness of intracellular penetration of ivermectin immobilized by corpuscular carriers. Biomeditsinskaya Khimiya, 53(1), 57-64.
Pristensky D.V. et al. Analysis of effectiveness of intracellular penetration of ivermectin immobilized by corpuscular carriers // Biomeditsinskaya Khimiya. - 2007. - V. 53. -N 1. - P. 57-64.
Pristensky D.V. et al., "Analysis of effectiveness of intracellular penetration of ivermectin immobilized by corpuscular carriers." Biomeditsinskaya Khimiya 53.1 (2007): 57-64.
Pristensky, D. V., Staroverov, S. A., Ermilov, D. N., Shchyogolev, S. Yu., Dykman, L. A. (2007). Analysis of effectiveness of intracellular penetration of ivermectin immobilized by corpuscular carriers. Biomeditsinskaya Khimiya, 53(1), 57-64.
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