Analysis of effectiveness of intracellular penetration of ivermectin immobilized by corpuscular carriers

   
Pristensky D.V.1, Staroverov S.A.1, Ermilov D.N.2, Shchyogolev S.Yu.1, Dykman L.A.1

1. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences
2. Research Center "Nita-Farm Co."
Section: Experimental/Clinical Study
PubMed Id: 17436685
Year: 2007  Volume: 53  Issue: 1  Pages: 57-64
Penetration of ivermectin adsorbed on the surface of colloidal gold particles or included in micelles to phagocytic immune system cells was studied. Detection of the preparation in the cells was carried out by an immunochemical method, employing miniantibodies to ivermectin obtained from a combinatory phage library and by a chromatographic method on the HPLC system "Stayer". It was found that ivermectin adsorbed on colloidal gold particles was accumulated in the cells most intensively.
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Keywords: ivermectin, colloidal gold, micelles, addressed drug delivery, phage miniantibodies, fluorescent microscopy
Citation:

Pristensky, D. V., Staroverov, S. A., Ermilov, D. N., Shchyogolev, S. Yu., Dykman, L. A. (2007). Analysis of effectiveness of intracellular penetration of ivermectin immobilized by corpuscular carriers. Biomeditsinskaya khimiya, 53(1), 57-64.
This paper is also available as the English translation: 10.1134/S1990750807030146
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