Previous studies demonstrated that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits inflammatory effects of the bacterial lipopolisacharide (LPS, endotoxin). In this work we have characterized the anti-endotoxin activity of other classes of oxidized phospholipids with different polar head groups and fatty acid residues. LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids. The anti-endotoxin effect insignificantly depended on the type of polyunsaturated fatty acids. Unoxidized phospholipids did not suppress effects of LPS. Thus, the anti-endotoxin activity of oxidized phospholipids crucially depends on the presence of oxidatively modified fatty acid residue.
Korotaeva A.A., Samokhodskaya L.M., Bochkov V.N. (2007) Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids. Biomeditsinskaya Khimiya, 53(1), 65-71.
Korotaeva A.A. et al. Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids // Biomeditsinskaya Khimiya. - 2007. - V. 53. -N 1. - P. 65-71.
Korotaeva A.A. et al., "Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids." Biomeditsinskaya Khimiya 53.1 (2007): 65-71.
Korotaeva, A. A., Samokhodskaya, L. M., Bochkov, V. N. (2007). Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids. Biomeditsinskaya Khimiya, 53(1), 65-71.
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