Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids

   
Korotaeva A.A.1 , Samokhodskaya L.M.2, Bochkov V.N.2

1. Russian Cardiology Scientific Research Center
2. Faculty of Basic Medicine, Lomonosov Moscow State University
Section: Experimental/Clinical Study
UDK: 547.915.5-547.458.2-577.15      PubMed Id: 17436686
Year: 2007  Volume: 53  Issue: 1  Pages: 65-71
Previous studies demonstrated that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits inflammatory effects of the bacterial lipopolisacharide (LPS, endotoxin). In this work we have characterized the anti-endotoxin activity of other classes of oxidized phospholipids with different polar head groups and fatty acid residues. LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids. The anti-endotoxin effect insignificantly depended on the type of polyunsaturated fatty acids. Unoxidized phospholipids did not suppress effects of LPS. Thus, the anti-endotoxin activity of oxidized phospholipids crucially depends on the presence of oxidatively modified fatty acid residue.
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Korotaeva A.A., Samokhodskaya L.M., Bochkov V.N. (2007) Biomeditsinskaya khimiya, 53(1), 65-71.
This paper is also available as the English translation:10.1134/S1990750807030080
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