Study of substrate specificity of a new peptide substrate of endothelin converting enzyme

   
Gureeva T.A.1, Kugaevskaya Е.V.1, Pozdnev V.F.1, Prozorovskiy V.N.1, Elisseeva Yu.Е.1, Solovyeva N.I.1

1. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
UDK: 577.152.341*51      PubMed Id: 17639718
Year: 2007  Volume: 53  Issue: 2  Pages: 172-180
The new fluorogenic hexapeptide substrate CMC-Ala-Gly-Gly-Trp-Phe-Arg was used as substrate for endothelin-converting enzyme (ECE), angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The specific inhibitors lisinopril (ACE) and thiorphan (NEP) were used for identification of these enzyme activities.
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Gureeva T.A., Kugaevskaya Е.V., Pozdnev V.F., Prozorovskiy V.N., Elisseeva Yu.Е., Solovyeva N.I. (2007) Biomeditsinskaya khimiya, 53(2), 172-180.
This paper is also available as the English translation:10.1134/S1990750807030055
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