Using the computer system SARD-21 (Structure Activity Relationship & Design) the structural features typical for high- and low- effective nonsteroid anti-inflammatory drugs (NSAIDs) were analyzed. This information has been used for the model for prediction of anti-inflammatory effectiveness of medicines with 76% and 81% level of recognition by two methods. New data can be used for creating new highly effective NSAIDs, and for increasing effectiveness of already known components.
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Keywords: Nonsteroidal anti-inflammatory drugs, theory of shape recognition, structure-activity, cyclooxygenase
Citation:
Khayrullina V.R., Mukhametov A.D., Tjurina L.A., Garifullina G.G., Gerchikov A.J., Zarudiy F.S. (2007) Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action". Biomeditsinskaya Khimiya, 53(3), 266-275.
Khayrullina V.R. et al. Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action" // Biomeditsinskaya Khimiya. - 2007. - V. 53. -N 3. - P. 266-275.
Khayrullina V.R. et al., "Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action"." Biomeditsinskaya Khimiya 53.3 (2007): 266-275.
Khayrullina, V. R., Mukhametov, A. D., Tjurina, L. A., Garifullina, G. G., Gerchikov, A. J., Zarudiy, F. S. (2007). Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action". Biomeditsinskaya Khimiya, 53(3), 266-275.
