Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action"

   
Khayrullina V.R.1, Mukhametov A.D.1 , Tjurina L.A.2, Garifullina G.G.1, Gerchikov A.J.1 , Zarudiy F.S.3

1. Bashkortostan State University
2. Ufa State Petroleum Technological University
3. Institute of Organic Chemistry, Ufa Science Centre of RAS
Section: Experimental/Clinical Study
PubMed Id: 17722576
Year: 2007  Volume: 53  Issue: 3  Pages: 266-275
Using the computer system SARD-21 (Structure Activity Relationship & Design) the structural features typical for high- and low- effective nonsteroid anti-inflammatory drugs (NSAIDs) were analyzed. This information has been used for the model for prediction of anti-inflammatory effectiveness of medicines with 76% and 81% level of recognition by two methods. New data can be used for creating new highly effective NSAIDs, and for increasing effectiveness of already known components.
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Keywords: Nonsteroidal anti-inflammatory drugs, theory of shape recognition, structure-activity, cyclooxygenase
Citation:

Khayrullina, V. R., Mukhametov, A. D., Tjurina, L. A., Garifullina, G. G., Gerchikov, A. J., Zarudiy, F. S. (2007). Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action". Biomeditsinskaya khimiya, 53(3), 266-275.
This paper is also available as the English translation: 10.1134/S199075080704004X
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