Oxidative metabolism and crystal-forming properties of blood of the experimental animals subjectedto nonsymmetrical dimethylhydrazine

   
Kulmagambetov I.R.1, Muravleva L.Ye.1 , Koikov V.V.1 , Abdrahmanova Yu.E.1

1. Karaganda State Medical Academy
Section: Experimental/Clinical Study
PubMed Id: 17722577
Year: 2007  Volume: 53  Issue: 3  Pages: 276-283
We have studied parameters of oxidative metabolism and crystal-forming properties of the rat blood under conditions of intoxication by nonsymmetrical dimethylhydrazine (NDMH). We have found the increase of secondary and end-products of lipid peroxidation in blood erythrocytes 7 days after NDMH injection at a dose of 5 mg/kg. Administration of a higher dose of NDMH (70 mg/kg) results in essential accumulation of initial, secondary and end-products of lipid peroxidation in rat erythrocytes, accumulation of products of protein oxidative modification in blood plasma. Studies of plasma crystal-forming properties have shown, that the increase of a dose of the injected toxicant causes the loss of ash value and symmetry in arrangement of basic elements of facies (concretions, separateness, cracks), changes of their shape or their full disappearance. There are abnormal fields (individual or plural tongue structures, "wrinkles", sheet structures, garrot-like structures etc.). Thus the bright picture of the plasma structure-forming properties is noted already at low NDMH doses. The results obtained suggest close interrelation between the impairments of physical and chemical properties of blood plasma in experimental animals under canditions of toxic action of NDMH.
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Keywords: nonsymmetrical dimethylhydrazine, oxidative metabolism, lipid peroxidation, oxidative modification of protein, theziografy
Citation:

Kulmagambetov, I. R., Muravleva, L. Ye., Koikov, V. V., Abdrahmanova, Yu. E. (2007). Oxidative metabolism and crystal-forming properties of blood of the experimental animals subjectedto nonsymmetrical dimethylhydrazine. Biomeditsinskaya khimiya, 53(3), 276-283.
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