Mechanisms of regulation of glycolytic enzymes in rat liver under morphine intoxication

   
Lelevich S.V.1

1. Grodno State Medical University
Section: Experimental/Clinical Study
PubMed Id: 17722578
Year: 2007  Volume: 53  Issue: 3  Pages: 284-289
The influence of acute morphine intoxication on glycolytic enzymes in liver has been investigated. The most significant changes were found under the action of the drug in the dose of 10 mg/kg. We also studied in vitro action of morphine in the concentrations 1, 10 and 50 μg/ml on the key glycolytic enzymes activities in rat liver. The direct dose-dependent inhibition of the glycokinase activity was shown. The changes in functional state of carbohydrate metabolism accompany hormonal imbalance in the animal bodies.
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Keywords: morphine, glycolysis, hexokinase, glycokinase, insuline, thyroxine
Citation:

Lelevich, S. V. (2007). Mechanisms of regulation of glycolytic enzymes in rat liver under morphine intoxication. Biomeditsinskaya khimiya, 53(3), 284-289.
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