Changes in free amino acid contents in the liver and heart under the conditions of restricted movement activity

Hakobyan V.P.1, Sotskiy O.P.1, Zhamharyan L.G.1

1. Yerevan State Medical University
Section: Experimental/Clinical Study
UDK: 615.2 : 515      PubMed Id: 17722581
Year: 2007  Volume: 53  Issue: 3  Pages: 307-312
The contents of the free amino acid in the liver and heart tissues were investigated under conditions of experimental hypokinesia on 15th, 30th and 45th days by means of HPLC method.The content of glutamate and aspartate in the liver tissue was sharply decreased with the increase of the hypokinesia period. The degree of the decrease of aspartate was more pronounced than glutamate. The level of glycine in the liver remained unchanged on 15th and 45th days of hypokinesia but increased on the 30th day compared with control animals. There were insignificant changes in taurine content. In contrast to the liver tissue the contents of monoaminodicarbonic acids were increased in the myocardum. The content of taurine was decreased over the whole period of restricted movement activity compared with control, especially on the 15th day of hypokinesia. The changes of free amino acids are discussed in terms of their participation in energy metabolism of both tissues during the restricted movement activity.
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Hakobyan V.P., Sotskiy O.P., Zhamharyan L.G. (2007) Biomeditsinskaya khimiya, 53(3), 307-312.
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