The aim of this study was to determine correlation between proteolysis parameters and phenotypes of α1-proteinase inhibitor in blood plasma in children with duodenal ulcer. Activation of pepsin- and trypsin like proteinases was accompanied by the decrease in activity of α2-macroglobulin and the increase in activity of acid stable inhibitors. The phenotypes М1М3, М1М1, М2М2 of α1-proteinase inhibitor were determined. Activation of proteolysis was more pronounced in individuals with subtype М2М2. Activity of α1-proteinase inhibitor decreased by 2-fold in М2М2, insignifically differed from the control group in М1М1, and increased by 1,9-fold in М1М3 subtype. Low activity of α1-proteinase inhibitor was accompanied by high activity of acid stable inhibitors; this may be regarded as the protective reaction of the body. Determination of α1-proteinase inhibitor phenotypes may be a basis for employment of polyvalent proteinase inhibitors for therapy of ulcer.
Akbasheva O.E. (2007) Parameters of plasma blood proteolysis and phenotypes ofα1-proteinase inhibitor in children with duodenal ulcer. Biomeditsinskaya Khimiya, 53(3), 338-344.
et al. Parameters of plasma blood proteolysis and phenotypes ofα1-proteinase inhibitor in children with duodenal ulcer // Biomeditsinskaya Khimiya. - 2007. - V. 53. -N 3. - P. 338-344.
et al., "Parameters of plasma blood proteolysis and phenotypes ofα1-proteinase inhibitor in children with duodenal ulcer." Biomeditsinskaya Khimiya 53.3 (2007): 338-344.
Akbasheva, O. E. (2007). Parameters of plasma blood proteolysis and phenotypes ofα1-proteinase inhibitor in children with duodenal ulcer. Biomeditsinskaya Khimiya, 53(3), 338-344.
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