Functional activity of phagocytes of bronchoalveolar lavage in patients with fibro-cavernosis and infiltrative pulmonary tuberculosis

Dyakova M.E.1 , Titarenko O.T.1, Esmedlyaeva D.S.1, Yelkin A.V.1, Alexeyeva N.P.1, Perova T.L.1

1. Federal Institution "Sant-Petersburg Scientific Reseach Institute of Phtisiopulmonology of Federal agency of Health and social development"
Section: Experimental/Clinical Study
UDK: 616.24-002.5-003.2:616.24-002.54:612.014.1      PubMed Id: 18078073
Year: 2007  Volume: 53  Issue: 5  Pages: 585-592
Functional activity of the bronchoalveolar lavage fluid (BALF) phagocytes was studied in 33 and 16 patients with fibro-cavernosis (FC) and infiltrative (I) pulmonary tuberculosis (PT), respectively. Complex examination of BALF, alveolar macrophages (AM) and neutrophils (N) sedimented from BALF revealed interrelationship between functional activity of the cells and the form of PT. Higher activities in BALF of neopterin and elastase mainly secreted by activated AM and N respectively, reflect a higher secretory activity of both types of cells in FC - PT. These patients are also characterized by more pronounced bactericide activity of Ns, which significantly correlates with adenosine deaminase (ADA) activity. It is suggested that changes in BALF of various biochemical parameters examined (neopterin, elastase, ADA and its isoenzymes, 2-deoxyADA) and bactericide activity of the sedimented cells represent are the consequences of differend sides of BALF phagocytes functioning. According to modern notions about the mechanisms of their regulation different intercellular relations are suggested in different form of PT.
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Dyakova M.E., Titarenko O.T., Esmedlyaeva D.S., Yelkin A.V., Alexeyeva N.P., Perova T.L. (2007) Biomeditsinskaya khimiya, 53(5), 585-592.
This paper is also available as the English translation:10.1007/s11828-008-1014-z
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