In the human myocardium tissue, proteomic technologies revealed the products of 2 genes (α-actin and albumin), existing as fragments; their appearance and increased contents correlated with age. The age-related variants differ from the mature forms by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-dependent proteins were found in 50% of cases (in the age group 31-40 years), while in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the cardiac musсle and also of the adaptation - dysadaptations mechanisms in the CIHD.
Kovalyova M.A., Kovalyov L.I., Serebryakova M.V., Moshkovskii S.A., Shishkin S.S. (2007) Age-related changes of albumin and actin of human myocardium. Biomeditsinskaya Khimiya, 53(6), 644-652.
Kovalyova M.A. et al. Age-related changes of albumin and actin of human myocardium // Biomeditsinskaya Khimiya. - 2007. - V. 53. -N 6. - P. 644-652.
Kovalyova M.A. et al., "Age-related changes of albumin and actin of human myocardium." Biomeditsinskaya Khimiya 53.6 (2007): 644-652.
Kovalyova, M. A., Kovalyov, L. I., Serebryakova, M. V., Moshkovskii, S. A., Shishkin, S. S. (2007). Age-related changes of albumin and actin of human myocardium. Biomeditsinskaya Khimiya, 53(6), 644-652.
Blackstock W. (2000) in Proteomics: A Trends Guide. (Blackstock W., Mann N. eds.) Elsevier-Science, London, рр. 12-17. Scholar google search
Skolnick J., Fetrow J.S., Kolinski I. (2000) Nature Biotechnol., 18, 283-287. Scholar google search
Шишкин С.С., Ковалёв Л.И., Громов П.С. (2000) в кн.: Многоликость современной генетики человека (под ред. Шишкина С.С.), Гилем, Москва, Уфа, с.17-50. Scholar google search
