Age-related changes of albumin and actin of human myocardium

   
Kovalyova M.A.1, Kovalyov L.I.1 , Serebryakova M.V.2, Moshkovskii S.A.2, Shishkin S.S.1

1. Bakh Institute of Biochemistry, Russian Academy of Sciences
2. Orekhovich Institute of Biomedical Chemistry RAMS
Section: Experimental/Clinical Study
UDK: 577.152.3.047      PubMed Id: 18323149
Year: 2007  Volume: 53  Issue: 6  Pages: 644-652
In the human myocardium tissue, proteomic technologies revealed the products of 2 genes (α-actin and albumin), existing as fragments; their appearance and increased contents correlated with age. The age-related variants differ from the mature forms by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-dependent proteins were found in 50% of cases (in the age group 31-40 years), while in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the cardiac musсle and also of the adaptation - dysadaptations mechanisms in the CIHD.
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Kovalyova M.A., Kovalyov L.I., Serebryakova M.V., Moshkovskii S.A., Shishkin S.S. (2007) Biomeditsinskaya khimiya, 53(6), 644-652.
This paper is also available as the English translation:10.1134/S1990750808020054
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