Entrapment of herbal extraxts in biodegradable microcapsules

Borodina T.N.1 , Rumsh L.D.2, Kunizhev S.M.1, Sukhorukov G.B.3, Vorozhtsov G.N.4, Feldman B.M.4, Rusanova A.V.5, Vasil'eva T.V.5, Strukova S.M.5, Markvicheva E.A.2

1. Stavropol State University
2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
3. Queen Mary University of London
4. Federal State Unitary Enterprise "State Scientific Centre "NIOPIK""
5. Lomonosov Moscow State University
Section: Experimental/Clinical Study
PubMed Id: 18323151
Year: 2007  Volume: 53  Issue: 6  Pages: 662-671
The microcapsules with entrapped herbal water-soluble extracts Plantago major and Calendula officinalis L. (HE) were prepared by LbL-adsorption of carrageenan and oligochitosan onto СаСО3 microparticles with their subsequent dissolving after the treatment of EDTA. Entrapment of HE was performed by adsorption and co-precipitation techniques. The co-precipitation provided better entrapment of HE compared to adsorption. In vitro release kinetics in an artificial gastric juice (AGJ) was studied. The HE release was shown to accelerate gastric ulcer treatment in a rat model.
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Keywords: microcapsules, herbal extracts, oligochitosan, carrageenan, pepsin, biodegradation, sustained drug release

Borodina, T. N., Rumsh, L. D., Kunizhev, S. M., Sukhorukov, G. B., Vorozhtsov, G. N., Feldman, B. M., Rusanova, A. V., Vasil'eva, T. V., Strukova, S. M., Markvicheva, E. A. (2007). Entrapment of herbal extraxts in biodegradable microcapsules. Biomeditsinskaya Khimiya, 53(6), 662-671.
This paper is also available as the English translation: 10.1134/S199075080802008X
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