The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats
1. Latvian Institute of Organic Synthesis 2. Latvian Institute of Organic Synthesis Faculty of Medicine, University of Latvia 3. Faculty of Medicine, University of Latvia
We have investigated effects of Mildronate, gamma-butyrobetaine (GBB) and their combination ("Neomildronate") on the plasma levels of thyroid gland hormones and some intermediats of basal metabolism (free fatty acids, triglycerides, glucose) in rats with different dysfunctions of thyroid gland, including idiopathic hyperfunction and hypofunction induced by propylthyouracil or L-carnitin administration. Histological investigation of the thyroid gland was also performed. Intraperitoneal injections of Mildronate (150 mg/kg) during 20 days to Wistar male rats with elevated level of thyroid hormones and basal metabolism normalized thyroxine level and parameters of lipid metabolism. Midldronate, GBB and their combination did not affect the natural resurgence of rats with experimental hypofunction induced by propylthyouracil or L-carnitin administration. The possible biochemical role of given treatment in regulation of thyroid gland function is discussed.
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Keywords: Mildronate and its derivatives, rat thyroid gland dysfunction, experimental models, thyroid hormones, intermediate products of basal metabolism in blood serum
Citation:
Sharipova J., Salna E., Dzintare M., Lauberte L., Meirena D., Sjakste N., Gordjushina V., Kalvinsh I. (2007) The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats. Biomeditsinskaya Khimiya, 53(6), 672-682.
Sharipova J. et al. The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats // Biomeditsinskaya Khimiya. - 2007. - V. 53. -N 6. - P. 672-682.
Sharipova J. et al., "The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats." Biomeditsinskaya Khimiya 53.6 (2007): 672-682.
Sharipova, J., Salna, E., Dzintare, M., Lauberte, L., Meirena, D., Sjakste, N., Gordjushina, V., Kalvinsh, I. (2007). The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats. Biomeditsinskaya Khimiya, 53(6), 672-682.
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