The main principles of the analysis and optimization of molecular conformation, which is the bases for molecular modeling methods in the field of bioinformatics, are briefly described. The basic approaches to molecular models energy minimization are considered. The given lecture is included into a theoretical cycle "Bioinformatics and computer aided drug design " for students of Medical and biologic faculty RGMU (biochemists, biophysics and medical cybernetics). It can be also recommended for other medical and biological students, as well as for PhD students.
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