Effect of single dose of arecholine and atropine administration on the carboxypeptidase h and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activities in the nerves system of rats

   
Solovev V.B.1 , Gengin M.T.1

1. Penza State Pedagogical University
Section: Experimental/Clinical Study
PubMed Id: 18522222
Year: 2008  Volume: 54  Issue: 2  Pages: 201-209
The effect of a single dose administration of arecholine and atropine on the activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase involved into the final stage of formation of biologically active neuropeptides from precursors has been studied. Changes in the enzyme activities were evident during at least 72 h after administration of these drugs. These results suggest that one of possible mechanisms of reduction of neuropeptide levels by arecholine and atropine consists in suppression of activity of enzymes taking part in there metabolism - carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase.
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Keywords: carboxypeptidase H, phenylmethylsulfonyl fluoride-inhibited carboxypeptidase, atropine, arecholine, neuropeptides, brain
Citation:

Solovev, V. B., Gengin, M. T. (2008). Effect of single dose of arecholine and atropine administration on the carboxypeptidase h and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activities in the nerves system of rats. Biomeditsinskaya khimiya, 54(2), 201-209.
This paper is also available as the English translation: 10.1134/S1990750808020091
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