Cystatin C belongs to the group of wide spread extracellular cysteine protease inhibitors. Using ELISA kits it was shown that the highest cystatin C concentration was in human cerebrospinal fluid and low cystatin C concentration was in human urine. In healthy young persons serum cystatin C concentration was lower than in elder patients (50-65 year old). In patients with hemoblastoses (lymphoma, lymphogranulomatosis) increased serum cystatin C concentration was normalized after effective antitumor therapy. According to these data one can conclude that serum cystatin C concentration can be used as one of the prognostic criteria in patients with several kinds of hemoblastoses.
Korolenko T.A., Filatova T.G., Cherkanova M.S., Khalikova T.A., Bravve I.Yu. (2008) Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation. Biomeditsinskaya Khimiya, 54(2), 210-217.
Korolenko T.A. et al. Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation // Biomeditsinskaya Khimiya. - 2008. - V. 54. -N 2. - P. 210-217.
Korolenko T.A. et al., "Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation." Biomeditsinskaya Khimiya 54.2 (2008): 210-217.
Korolenko, T. A., Filatova, T. G., Cherkanova, M. S., Khalikova, T. A., Bravve, I. Yu. (2008). Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation. Biomeditsinskaya Khimiya, 54(2), 210-217.
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