Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation

   
Korolenko T.A.1 , Filatova T.G.1, Cherkanova M.S.2, Khalikova T.A.1, Bravve I.Yu.2

1. Institute of Physiology Siberian Branch of Russian Academy of Medical Sciences
2. Novosibirsk Regional Cardiology Unit
Section: Experimental/Clinical Study
PubMed Id: 18522223
Year: 2008  Volume: 54  Issue: 2  Pages: 210-217
Cystatin C belongs to the group of wide spread extracellular cysteine protease inhibitors. Using ELISA kits it was shown that the highest cystatin C concentration was in human cerebrospinal fluid and low cystatin C concentration was in human urine. In healthy young persons serum cystatin C concentration was lower than in elder patients (50-65 year old). In patients with hemoblastoses (lymphoma, lymphogranulomatosis) increased serum cystatin C concentration was normalized after effective antitumor therapy. According to these data one can conclude that serum cystatin C concentration can be used as one of the prognostic criteria in patients with several kinds of hemoblastoses.
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Keywords: cystatins, cysteine proteases, tumors, atherosclerosis
Citation:

Korolenko, T. A., Filatova, T. G., Cherkanova, M. S., Khalikova, T. A., Bravve, I. Yu. (2008). Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation. Biomeditsinskaya khimiya, 54(2), 210-217.
This paper is also available as the English translation: 10.1134/S1990750808030104
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