Molecular characteristics of testosterone binding globulin (TeBG) were investigated in microaliquots of human serum samples using 3H-5-α-dihydrotestosterone radioligand assays. Under experimental conditions used TeBG demonstrated high conformational plasticity and ability to adopt three conformational states (olygo-, di-, and monomer) with different functional activities. Using a lipidspolyene complex from basidiomycete Laetiporus sulphureus we demonstrate a novel effective pharmacological correction of the TeBG characteristics.
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Keywords: testosterone binding globulin, lipidspolyene complex of Laetiporus sulphureus
Citation:
Popoff E.H., Kapich A.N. (2008) Molecular characteristics of testosterone binding globulin and analysis of their regulation. Biomeditsinskaya Khimiya, 54(3), 349-360.
Popoff E.H. et al. Molecular characteristics of testosterone binding globulin and analysis of their regulation // Biomeditsinskaya Khimiya. - 2008. - V. 54. -N 3. - P. 349-360.
Popoff E.H. et al., "Molecular characteristics of testosterone binding globulin and analysis of their regulation." Biomeditsinskaya Khimiya 54.3 (2008): 349-360.
Popoff, E. H., Kapich, A. N. (2008). Molecular characteristics of testosterone binding globulin and analysis of their regulation. Biomeditsinskaya Khimiya, 54(3), 349-360.
