Molecular characteristics of testosterone binding globulin and analysis of their regulation

   
Popoff E.H.1 , Kapich A.N.2

1. Institute of Radiobiology, Belarus Nat. Acad. Sci
2. International Sakharov Environmental University
Section: Experimental/Clinical Study
UDK: 612.12.018:577.175.62:].08      PubMed Id: 18712090
Year: 2008  Volume: 54  Issue: 3  Pages: 349-360
Molecular characteristics of testosterone binding globulin (TeBG) were investigated in microaliquots of human serum samples using 3H-5-α-dihydrotestosterone radioligand assays. Under experimental conditions used TeBG demonstrated high conformational plasticity and ability to adopt three conformational states (olygo-, di-, and monomer) with different functional activities. Using a lipidspolyene complex from basidiomycete Laetiporus sulphureus we demonstrate a novel effective pharmacological correction of the TeBG characteristics.
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Popoff E.H., Kapich A.N. (2008) Biomeditsinskaya khimiya, 54(3), 349-360.
This paper is also available as the English translation:10.1134/S1990750808040094
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