The perspectives of hepatic failure treatment by stem cells

Dolgikh M.S.

The perspectives of hepatic failure treatment by stem cells

Dolgikh M.S.¹

1. Institute of Transplantology and Artificial Organs, Rosmedtechnology

Section: Review

PubMed Id: 18988455

Year: 2008 Volume: 54 Issue: 4 Pages: 376-391

The insufficiency of liver functions remains one of the major causes of death. The liver transplantation is the most effective method for treating severe liver diseases. The shortage of donor organs and high risk of graft rejection are the main problems for liver transplantation. Stem cells and isolated hepatocytes are alternative means for repopulating the liver after various injuries instead of liver transplantation. This review analyses the experimental and clinical advantage and perspectives on the stem cells use in clinical trials for treating hepatic failure.

Download PDF:

Keywords: cell therapy, stem cells, hepatic failure

Citation:

Dolgikh, M. S. (2008). The perspectives of hepatic failure treatment by stem cells. Biomeditsinskaya Khimiya, 54(4), 376-391.

This paper is also available as the English translation: 10.1134/S1990750808030074

References

Masson S., Harrison D.J., Plevris J.N., Newsome P.N. (2004) Stem Cells, 22, 897-907. CrossRef Scholar google search
Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., Pickel J., McKay R. Nadal-Ginard B ., Bodine D.M., Leri A., Anversa P. (2001) Nature, 410(6829), 701-705. CrossRef Scholar google search
Jackson K.A., Majka S.M., Wang H., Pocius J., Hartley C.J., Majesky M.W., Entman M.L., Michael L.H., Hirschi K.K., Goodell M.A. (2001) J. Clin.Invest., 107, 1395-1402. CrossRef Scholar google search
Orlic D., Kajstura J., Chimenti S. (2001) Proc. Natl. Acad. Sci. USA., 98, 10344-10349. CrossRef Scholar google search
Potapov I.V., Kirillov I.A., Onischenko N.A. (2007) Kletochnaya transplantologiya i tkanevaya inzheneriya, 2, 45-51. Scholar google search
Clarke D.L., Johansson C.B., Wilbertz J., Veress B., Nilsson E., Karlstrцm H., Lendahl U., Frisйn J. (2000) Science, 288, 1660-1663. CrossRef Scholar google search
PetersenB.E., Bowen W.C., Patrene K.D., Mars W.M., Sullivan A.K., Murase N., Boggs S.S., Greenberger J.S., Goff J.P. (1999) Science, 284, 1168-1170. CrossRef Scholar google search
Theise N.D., Badve S., Saxena R., Henegariu O., Sell S., Crawford J.M., Krause D.S. (2000) Hepatology, 31, 235-240. CrossRef Scholar google search
Krause D.S., Theise N.D., Collector M.I., Henegariu O., Hwang S., Gardner R., Neutzel S., Sharkis S.J. (2001) Cell, 105(3), 369-377. Scholar google search
Farber E. (1956) Cancer Res., 16, 142-148. Scholar google search
Yin L., Lynch D., Ilic Z., Sell S. (2002) Histol. Histopathol., 17, 65-81. Scholar google search
Gordon G.J., Coleman W.B., Hixson D.C., Grisham J.W. (2000) Am. J. Pathol., 156(2), 607-619. Scholar google search
Sell S. (2001) Hepatology, 33, 738-750. Scholar google search
Alison M.R., Poulson R., Jeffrey R., Dhillon A.P., Quaglia A., Jacob J., Noveelli M., Prentice G., Williamson J., Wright N.A. (2000) Nature, 406, 257-258. Scholar google search
Alison M.R. (2002) Transplant. Proc., 34, 2702-2705. Scholar google search
Rhim J.A., Sandgren E.P., Degen J.L., Palmiter R.D., Brinster R.L. (1994) Science, 263, 1149-1152. CrossRef Scholar google search
Overturf K., al-Dhalimy M., Tanguay R., Brantly M., Ou C.N., Finegold M., Grompe M. (1996) Nature Genet., 12, 266-273. Scholar google search
Laconi E., Sarma D.S.R., Pani P. (1995) Carcinogenesis, 16, 139-142. Scholar google search
Lowes K.N., Croager E.J., Olynyk J.K., Abraham L.J., Yeoh G.C.T. (2003) J. Gastroenterol. Hepatol., 18, 4-12. Scholar google search
Alison M.R. (1998) Curr. Opin. Cell Biol., 10, 710-715. Scholar google search
Theise N.D., Saxena R., Portmann B.C., Thung S.N., Yee H., Chiriboga L., Kumar A., Crawford J.M. (1999) Hepatology, 30(6), 1425-1433. Scholar google search
Sell S. (1998) Hepatology, 27, 317-331. Scholar google search
Feldman G. (2001) Cell Biol. Toxicol., 17, 77-85. Scholar google search
Yasui O., Miura N., Kawarada K., Koyama K., Sugiyama T. (1997) Hepatology, 25, 329-334. Scholar google search
Krakowski M.L., Kritzik M.R., Jones E.M., Krahl T., Lee J., Arnush M., Gu D., Sarvetnick N. (1999) Am. J. Pathol., 154(3), 683-691. Scholar google search
Shen C.N., Slack J.M., Tosh D. (2000) Nat. Cell Biol., 2, 879-887. Scholar google search
Goodell M.A., Rosenzweig M., Kim H., Marks D.F., DeMaria M., Paradis G., Grupp S.A., Sieff C.A., Mulligan R.C., Johnson R.P. (1997) Nat. Med., 3(12), 1337-1345. Scholar google search
Yin A.H., Miraglia S., Zanjani E.D., Almeida-Porada G., Ogawa M., Leary A.G., Olweus J., Kearney J., Buck D.W. (1997) Blood, 90(12), 5002-5012. Scholar google search
Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., Wang X., Feingold M., Weisman J.L., Grompe M. (2000) Nat.Med., 6, 1229-1234. Scholar google search
Mallet V.O., Mitchell C., Mezey E., Fabre M., Guidotti J.E., Renia L., Coulombel L., Kahn A., Gilgenkrantz H. (2002) Hepatology, 35(4), 799-804. Scholar google search
Terai S., Sakaida I., Yamamoto N., Omori K., Watanabe T., Ohata S., Katada T., Miyamoto K., Shinoda K., Nishina H., Okita K. (2003) J. Biochem. Tokyo, 134(4), 551-558. Scholar google search
Wulf G.G., Luo K.L., Jackson K., Brenner M.K., Goodell M.A. (2003) Haematologica, 88(4), 368-378. Scholar google search
Goodell M.A., Brose K., Paradis G., Conner A.S., Mulligan R.C. (1996) J. Exp. Med., 183(4), 1797-1806. Scholar google search
Theise N.D., Krause D.S., Sharkis S. (2003) Science, 299, 1317. CrossRef Scholar google search
Wagers A.J., Sherwood R.I., Christensen J.L.,Weissman I.L. (2002) Science, 297(5590), 2256-2259. CrossRef Scholar google search
Dahlke M.H., Popp F.C., Bahlmann F.H., Aselmann H., Jдger M.D., Neipp M., Piso P., Klempnauer J., Schlitt H.J. (2003) J. Hepatol., 39, 365-367. Scholar google search
Allen J.W. (2002) Tissue Engineering, 8, 725-737. Scholar google search
Barrileaux B., Phinney D.G., Prockop D.J., O`Connor K.C. (2006) Tissue Engineering, 12(11), 3007-3019. Scholar google search
Thorgeirsson S.S. (1996) FASEB J., 10, 1249- 1256. Scholar google search
Rudolph K.L., Chang S., Millard M.,Schreiber-Agus N., De Pinho R.A. (2000) Science, 287(5456), 1253-1258. CrossRef Scholar google search
Theise N.D., Nimmakayalu M., Gardner R., Illei P.B., Morgan G., Teperman L., Henegariu O., Krause D.S. (2000) Hepatology, 32, 11-16. Scholar google search
Shafritz D.A., Dabeva M.D. (2002) Einstein Quart. J. Biol. Med., 19, 20-32. Scholar google search
Evarts R.P., Nagy P., Marsden E., Thorgeirsson S.S. (1987) Carcinogenesis, 8, 1737-1740. Scholar google search
Evarts R.P., Nagy P., Nakatsukasa H., Marsden E., Thorgeirsson S.S. (1989) Cancer Res., 49, 1541-1547. Scholar google search
Thorgeirsson S.S. (1993) Am. J. Pathol., 142, 1331-1333. Scholar google search
Abelev G.I. (1971) Adv. Cancer Res., 14, 295-358. Scholar google search
Overturf K., Al-Dhalimy M., Ou C.N., Finegold M., Grompe M. (1997) Am. J. Pathol., 151, 1273-1280. Scholar google search
Wang X., Al-Dhalimy M., Lagasse E., Finegold M., Grompe M. (2001) Am. J. Pathol., 158(2), 571-579. Scholar google search
Sandgren E.P., Palmiter R.D., Heckel J.L., Daugherty C.C., Brinster R.L., Degan J.L. (1991) Cell, 66, 245-256. Scholar google search
Rhim J.A., Sandgren E.P., Palmiter R.D.,Brinster R.L. (1995) Proc.Natl. Acad. Sci. USA, 92(11), 4942-4946. Scholar google search
Jamal H.Z., Weglarz T.C., Sandgren E.P. (2000) Gastroenterology, 118(2), 390-394. Scholar google search
Weglarz T.C., Degen J.L., Sandgren E.P. (2000) Am. J. Pathol., 157, 1963-1974. Scholar google search
Dandri M., Burda M.R., Torok E., Pollok J.M., Iwanska A., Sommer G., Rogilrs X., Rogler C.E., Gupta S., Will H., Greten H., Petersen J. (2001) Hepatology, 33, 981-988. Scholar google search
Peterson J., Dandri M., Gupta S., Rogler C.E. (1998) Proc. Natl. Acad. Sci. USA, 95, 310-313. Scholar google search
Mignon A., Guidotti J.E., Mitchell C., Fabre M., Wernet A., De La Coste A., Soubrane O., Gilgenkrantz H., Kahn A. (1998) Nat. Med., 4, 1185-1188. Scholar google search
Thompson N.L., Hixson D.C., Calliavan H., Panzica M., Flanagan D., Faris R.A., Hong W., Hartel-Schenk S., Doyle D. (1991) Biochem. J., 273, 497-502. Scholar google search
Gupta S., Rajvanshi P., Lee D.C. (1995) Proc. Natl. Acad. Sci. USA, 92, 5860-5864. Scholar google search
Dabeva M.D., Hwang S.G., Vasa S.R.G., Novikoff P.M., Hixson D.C., Gupta S., Shafritz D.A. (1997) Proc.Natl. Acad. Sci. USA, 94, 7356-7361. Scholar google search
Gupta S., Chowdhury N.R., Jagtiani R., Gustin K., Shafritz D.A., Chowdhury J.R., Burk R.D. (1990) Transplantation, 50, 472-475. Scholar google search
Ponder K.P., Gupta S., Leland F., Darlington G., Finegold M., DeMayo J., Ledley F.D., Chowdhury J.R., Woo S.L. (1991) Proc.Natl. Acad. Sci. USA, 88, 1217-1221. Scholar google search
Laconi E., Oren R., Mukhopadhyay D., Hurston E., Laconi S., Pani P., Dabeva M.D., Shafritz D.A. (1998) Am. J. Pathol., 153, 319-329. Scholar google search
Samuel A., Jago M.V. (1975) Chem. Biol. Interact., 10, 185-197. Scholar google search
Oren R., Dabeva M., Petkov P., Hurston E., Laconi E., Shafritz D.A. (1999) Hepatol., 29, 75-81. Scholar google search
Dabeva M.D., Shafritz D.A. (1993) Am. J. Pathol., 143, 1606-1620. Scholar google search
Guha C., Sharma A., Gupta S., Alfieri A., Gorla G.R., Gagandeep S., Sokhi R., Roy-Chowdhury N., Tanaka K.E., Vikram B., Roy-Crowdhury J. (1999) Cancer Res., 59, 5871-5874. Scholar google search
Suzuki A., Zheng Y., Kondo R., Kusakabe M., Takada Y., Fukao K., Nakauchi H., Taniguchi H. (2000) Hepatology, 32, 1230-1239. Scholar google search
Fujiio K., Evarts R.P., Marsden E.R., Thorgeirsson S.S. (1994) Lab. Invest., 70, 511-516. Scholar google search
Crosby H.A., Kelly D.A., Strain A.J. (2001) Gastroenterology, 120, 534-544. Scholar google search
Kubota H., Reid L.M. (2000) Proc. Nat. Acad. Sci. USA, 97, 12132-12137. Scholar google search
Overturf K, Al-Dhalimy M, Finegold M., Grompe M. (1999) Am. J. Pathol., 155, 2135-2143. Scholar google search
Katayama S., Tateno C., Asahara T. (2001) Am. J. Pathol., 158, 97-105. Scholar google search
Sandhu J.S., Petkov P.M., Dabeva M.D., Shafritz D.A. (2001) Am. J. Pathol., 159, 1323-1334. Scholar google search
Coleman W.B., Wennerberg A.E., Smith G.J., Grisham J.W. (1993) Am. J. Pathol., 142, 1373-1382. Scholar google search
Liechty K.W., MacKenzie T.C., Shaaban A.F., Radu A., Moseley A.M., Deans R., Marshak D.R., Flake A.W. (2000) Nat. Med., 6(11), 1282-1286. Scholar google search
Parekkadan B.,van Poll D.,Suganuma K.,Carter E.A., Berthiaume F., Tilles A.W., Yarmush M.L. (2007) PLoS ONE, 2(9), e4941 . CrossRef Scholar google search
Fox I.J., Chowdhury J.R., Kaufman S.S.,Goertzen T.C., Chowdhury N.R., Warkentin P.I., Dorko K., Sauter B.V., Strom S.C. (1998) N. Engl. J. Med., 338, 1422-1426. Scholar google search
Gao Z.,McAlister V.C., Williams G.M. (2001) Lancet, 357, 932-933. Scholar google search
Thomas E.D. (2005) Int. J. Hematol., 81, 89-93. Scholar google search
Esche II J.S., Knoefel W.T., Klein M., Ghodsizad A., Fuerst G., Poll L.W., Piechaczek C., Burchardt E.R., Feifel N., Stoldt V., Stockschlader M., Stoecklein N., Tustas R.Y., Eisenberger C.F., Peiper M., Haussinger D., Hosch S.B. (2005) Stem Cells, 23(4), 463-470. Scholar google search
Gordon M.Y., Levicar N., Pai M., Bachellier P., Dimarakis I., Al-Allaf F., M`Handi H., Thalji T., Welsh J.P., Marley S.B., Davies J., Dazzi F., Marelli-Berg F., Tait P., Playford R., Jiao L., Jensen S., Nicholls J.P., Ayav A., Nohandani M., Farzaneh F., Gaken J., Dodge R., Alison M., Apperley J.F., Lechler R., Habib N.A. (2006) Stem Cells, 24(7), 1822-1830. Scholar google search
Stamm C.,Westphal B., Kleine H.D., Petzsch M., Kittner C., Klinge H., Schumichen, Nienaber C.A., Freund M., Steinhoff G. (2003) Lancet, 361, 45-46. Scholar google search
Pompilio G., Cannata A., Peccatori F., Bertolini F., Nascimbene A., Capogrossi M.C., Biglioli P. (2004) Ann. Thorac.Surg., 78, 1808-1813. Scholar google search
Singh S.K., Clarke I.D., Terasaki M., Bonn V.E., Hawkins C., Squire J., Dirks P.B. (2004) Cancer Res., 432, 396-400. Scholar google search
Summers Y.J., Heyworth C.M., de Wynter E.A., Hart C.A., Chang J., Testa N.G. (2004) Stem Сells, 22(5), 704-715. Scholar google search
Boyer L.A., Lee T.I., Cole M.F., Johnston S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., Gifford D.K., Melton D.A., Jaenisch R., Young R.A. (2005) Cell, 122(6), 947-956. Scholar google search
Pera M.F., Trounson A.O. (2004) Development, 131, 5515-5525. Scholar google search
Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waaknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M. (1998) Scince, 282, 1145-1147. Scholar google search

2024 (vol 70)
2023 (vol 69)
2022 (vol 68)
2021 (vol 67)
2020 (vol 66)
2019 (vol 65)
2018 (vol 64)
2017 (vol 63)
2016 (vol 62)
2015 (vol 61)
2014 (vol 60)
2013 (vol 59)
2012 (vol 58)
2011 (vol 57)
2010 (vol 56)
2009 (vol 55)
2008 (vol 54)

Issue 6
Issue 5
Issue 4
Issue 3
Issue 2
Issue 1

2007 (vol 53)
2006 (vol 52)
2005 (vol 51)
2004 (vol 50)
2003 (vol 49)

◄ ►