Native and chiral modified (with non-enzymatic Asn racemization) NR1-binding core of NMDA-receptor was modelled by means of molecular dynamic ligand modelling. It was concluded that Gly, D-Ser, D-Asn and D-Thr are ligands of NR1-binding core native NMDA-receptor, whereas the chiral modified NR1-binding core is characterized by the aliphatic non-polar amino acids D-Ala, D-Leu, D-Ile and D-Pro as ligands. The latter amino acids can be considered as effective ligands of NMDA-receptor NR1-binding core in age-related pathology.
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Keywords: NMDA-receptor, non-enzymatic racemization, ligands of NR1-binding core, molecular dynamics
Korotina A.S. et al. Native and chiral modified NMDA-receptor NR1-binding core ligands modeling // Biomeditsinskaya Khimiya. - 2008. - V. 54. -N 4. - P. 477-481.
Korotina A.S. et al., "Native and chiral modified NMDA-receptor NR1-binding core ligands modeling." Biomeditsinskaya Khimiya 54.4 (2008): 477-481.
Korotina, A. S., Dmitriev, A. V., Tverdislov, V. A. (2008). Native and chiral modified NMDA-receptor NR1-binding core ligands modeling. Biomeditsinskaya Khimiya, 54(4), 477-481.
