Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis

Kondakova I.V.1 , Klisho E.V.1, Savenkova O.V.1, Kakurina G.V.1, Choinzonov E.L.1, Shishkin D.A.1, Muhamedov M.R.1

1. Cancer Research Institute, Tomsk Scientific Centre of Siberian Branch of RAMS
Section: Experimental/Clinical Study
PubMed Id: 19105397
Year: 2008  Volume: 54  Issue: 5  Pages: 555-560
The levels of metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-2) and extracellular matrix metalloproteinase inducer (EMMPRIN) were studied in tumor tissue and blood serum from patients with head and neck squamous sell carcinoma. Immunohistochemical investigation showed muсh higher expression of MMP-9 and TIMP-1 in tumor tissue than MMP-2 and TIMP-2. Different expression of the studied parameters (except TIMP-1) in cancer cells and stroma was observed. Enhanced level of MMP-2,-9 and TIMP-2 expression was revealed mainly in fibrocytes, leukocytes and stromal extracellular matrix. Expression of EMMPRIN in tumor cells was higher than in stromal cells. It is possible that carcinoma cells express EMMPRIN to increase MMP production by surrounding cells. Significant decrease of inhibitor expression was observed in cells of carcinomas with N1 grade of metastasis than in tumors without metastasis. Also the decrease in TIMP-1 level was determined in blood serum of patients with metastasis to regional lymph nodes compared with serum of patients without metastasis. Thus, MMP-9 and TIMP-1 play an important role in the development of head and neck squamous sell carcinoma and TIMP-1 level in blood serum and cancer tissues is linked to first grade of regional lymph node metastasis.
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Keywords: matrix metalloproteinases, tissue inhibitors of metalloproteinases, extracellular matrix metalloproteinase inducer, head and neck squamous cell carcinoma, metastasis

Kondakova, I. V., Klisho, E. V., Savenkova, O. V., Kakurina, G. V., Choinzonov, E. L., Shishkin, D. A., Muhamedov, M. R. (2008). Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis. Biomeditsinskaya Khimiya, 54(5), 555-560.
This paper is also available as the English translation: 10.1134/S1990750808030116
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