A comparative kinetic study of the inhibition of urea hydrolysis by 9 substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones (BI I-IX) has been carried out. The inhibition had reversible competitive character; the inhibition constants Ki, varied from 29 up to 754 μM in dependence of the structure of BI I-IX. Three BI I-III, having the Ki values from 29 to 82 μM, may be used as the potential therapeutic agents for gastroenterology for treatment of stomach and duodenal ulcers.
Tarun E.I., Zheldakova T.A., Metelitza D.I. (2008) Substituted 1,5,6,7-tetrahydro-4h-benzimidazol-4-ones as inhibitors of urease. Biomeditsinskaya Khimiya, 54(5), 588-596.
Tarun E.I. et al. Substituted 1,5,6,7-tetrahydro-4h-benzimidazol-4-ones as inhibitors of urease // Biomeditsinskaya Khimiya. - 2008. - V. 54. -N 5. - P. 588-596.
Tarun E.I. et al., "Substituted 1,5,6,7-tetrahydro-4h-benzimidazol-4-ones as inhibitors of urease." Biomeditsinskaya Khimiya 54.5 (2008): 588-596.
Tarun, E. I., Zheldakova, T. A., Metelitza, D. I. (2008). Substituted 1,5,6,7-tetrahydro-4h-benzimidazol-4-ones as inhibitors of urease. Biomeditsinskaya Khimiya, 54(5), 588-596.
