1. Orekhovich Institute of Biomedical Chemistry Russian Academy of Medical Sciences 2. Research Institute of Genetics 3. Research Institute of Human Morphology Russian Academy of Medical Sciences
The cytotoxic activity of L-asparaginases from Yersinia pseudotuberculosis and from Erwinia carotovora were investigated in vitro using several tumor cells lines: Jurkat and Molt-4 (human T-lymphoblastic leukemia), MCF-7 (human breast adenocarcinoma), LnCap (human prostate carcinoma), NGUK1 (rat Gasser node neurinoma). E. coli L-asparaginase produced by "Medak" (Germany) was used as a reference. The cell growth inhibition data indicate that Y. pseudotuberculosis L-asparaginase significantly inhibits growth of leukemic and solid tumor cells. These results allow us to conclude that this L-asparaginase can be used for the development of new preparations for the therapy of different types of tumors.
Abakumova O.Yu. et al. Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis // Biomeditsinskaya Khimiya. - 2008. - V. 54. -N 6. - P. 712-719.
Abakumova O.Yu. et al., "Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis." Biomeditsinskaya Khimiya 54.6 (2008): 712-719.
Abakumova, O. Yu., Podobed, O. V., Borisova, A. A., Sidoruk, K. V., Alexandrova, S. S., Omelyanuk, N. M., Pokrovskaya, M. V., Kondakova, L. I., Sokolov, N. N. (2008). Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis. Biomeditsinskaya Khimiya, 54(6), 712-719.
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