Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis

Abakumova O.Yu.1 , Podobed O.V.1, Borisova A.A.1, Sidoruk K.V.2, Alexandrova S.S.1, Omelyanuk N.M.1, Pokrovskaya M.V.1, Kondakova L.I.3, Sokolov N.N.1

1. Orekhovich Institute of Biomedical Chemistry Russian Academy of Medical Sciences
2. Research Institute of Genetics
3. Research Institute of Human Morphology Russian Academy of Medical Sciences
Section: Short Communication
PubMed Id: 19205431
Year: 2008  Volume: 54  Issue: 6  Pages: 712-719
The cytotoxic activity of L-asparaginases from Yersinia pseudotuberculosis and from Erwinia carotovora were investigated in vitro using several tumor cells lines: Jurkat and Molt-4 (human T-lymphoblastic leukemia), MCF-7 (human breast adenocarcinoma), LnCap (human prostate carcinoma), NGUK1 (rat Gasser node neurinoma). E. coli L-asparaginase produced by "Medak" (Germany) was used as a reference. The cell growth inhibition data indicate that Y. pseudotuberculosis L-asparaginase significantly inhibits growth of leukemic and solid tumor cells. These results allow us to conclude that this L-asparaginase can be used for the development of new preparations for the therapy of different types of tumors.
Download PDF:  
Keywords: L-asparaginase, tumor cells, cytotoxicity, Yersinia pseudotuberculosis

Abakumova, O. Yu., Podobed, O. V., Borisova, A. A., Sidoruk, K. V., Alexandrova, S. S., Omelyanuk, N. M., Pokrovskaya, M. V., Kondakova, L. I., Sokolov, N. N. (2008). Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis. Biomeditsinskaya Khimiya, 54(6), 712-719.
This paper is also available as the English translation: 10.1134/S1990750809020115
 2024 (vol 70)
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)