The role of changes of matrix metalloproteinase in cardiovascular diseases

   
Gasanov A.G.1, Bershova T.V.1

1. Federal State Budgetary Institution “Scientific Centre of Children Health” under the RAMS
Section: Review
PubMed Id: 19507339
Year: 2009  Volume: 55  Issue: 2  Pages: 155-168
The review summarizes information about changes of extracellular matrix (ECM) in cardiovascular diseases. Special attention is paid to different groups of extra cellular matrix proteins (collagen I and III type, fibronectine) in the development of cardiac fibrosis in chronic heart failure. The role of matrix metalloproteinases in degradation of components of ECM is analyzed. Interrelationship between matrix metalloproteinases and their tissue inhibitors in fibrosis and cardiac structural chances is analyzed.
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Keywords: chronic heart failure, cardiovascular disease, extracellular matrix, matrix metalloproteinase, inhibitor of matrix metalloproteinase
Citation:

Gasanov, A. G., Bershova, T. V. (2009). The role of changes of matrix metalloproteinase in cardiovascular diseases. Biomeditsinskaya khimiya, 55(2), 155-168.
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