Possibilities for use of phospholipid nanosystem with glycyrrhizic acid ("phosphogliv") for optimization of drugs: doxorubicin and budesonide as examples
The complexes of phospholipids nanoparticles (as the injection form of newly developed hepatoprotector phosphogliv) with the antitumor drug doxorubicin or with glucocorticoid budesonide have been investigated for their pharmacological activity in comparison with free forms of these drugs. Doxorubicin with phosphogliv revealed more antitumor and antimetastatic activity in С47В1/6 mice with carcinoma LLC than free doxorubicin. Inhalation of budesonide with phosphogliv in vivo to quinea pigs resulted to more pronounced decrease of antigen or histamin induced bronchospasm, particularly its subacute phase, as compared with traditional powder or suspension budesonide forms. This suggests that the phosphogliv injection forms may be used not only for treatment of liver diseases, but also for delivery of a number of other drugs and consequently for optimization of their efficiency.
Ipatova O.M., Zykova M.G., Prozorovskii V.N., Torkhovskaya T.I., Zakharova T.S. (2009) Possibilities for use of phospholipid nanosystem with glycyrrhizic acid ("phosphogliv") for optimization of drugs: doxorubicin and budesonide as examples. Biomeditsinskaya Khimiya, 55(2), 185-194.
Ipatova O.M. et al. Possibilities for use of phospholipid nanosystem with glycyrrhizic acid ("phosphogliv") for optimization of drugs: doxorubicin and budesonide as examples // Biomeditsinskaya Khimiya. - 2009. - V. 55. -N 2. - P. 185-194.
Ipatova O.M. et al., "Possibilities for use of phospholipid nanosystem with glycyrrhizic acid ("phosphogliv") for optimization of drugs: doxorubicin and budesonide as examples." Biomeditsinskaya Khimiya 55.2 (2009): 185-194.
Ipatova, O. M., Zykova, M. G., Prozorovskii, V. N., Torkhovskaya, T. I., Zakharova, T. S. (2009). Possibilities for use of phospholipid nanosystem with glycyrrhizic acid ("phosphogliv") for optimization of drugs: doxorubicin and budesonide as examples. Biomeditsinskaya Khimiya, 55(2), 185-194.
References
Jiang W., Kim B.Y., Rutka J.T., Chan W.C. (2007) Expert Opin. Drug Deliv., 4, 621-633. Scholar google search
Siepmann F., Siepmann J., Walther M., MacRae R.J., Bodmeier R. (2008) J. Control Release, 125, 1-15. Scholar google search
Ипатова О.М. (2005) Фосфоглив: механизм действия и применение в клинике. Изд-во ГУ НИИ БМХ РАМН, М. Scholar google search
Ковалева В.Л. (2000) Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ. М., 242-248. Scholar google search
Федосеева В.Н., Порядин Г.В., Ковальчук Л.В. (1993) Руководство по иммунологическим и аллергологическим методам в гигиенических исследованиях. Промедэк, М. Scholar google search
