Oral insulin preparations for the regulation of the glucose level in the blood

Valuev L.I.1 , Sytov G.A.1, Valuev I.L.1, Vanchugova L.V.1, Valueva T.A.2 , Plate N.A.1, Starosel'tseva L.K.3 , Ul'yanova M.V.1

1. A.V. Topchiev Institute of petrochemical synthesis, Russian Academy of Sciences
2. A.N. Bakh Institute of Biochemistry, Russian Academy of Sciences
3. Scientific Center of Endocrinology, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
PubMed Id: 19507343
Year: 2009  Volume: 55  Issue: 2  Pages: 195-200
Oral administration of diluted solutions of insulin results in the absorption of the hormone into bloodstream. After oral administration of diluted insulin solutions to healthy volunteers and animals with experimental diabetes insulin does not undergo hydrolytic degradation under the action of proteolytic enzymes and its absorption is sufficient to produce the hypoglycemic effect. This approach gives a chance of creating of novel strategy for diabetes treatment.
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Keywords: diabetes, insulin, diluted solution

Valuev, L. I., Sytov, G. A., Valuev, I. L., Vanchugova, L. V., Valueva, T. A., Plate, N. A., Starosel'tseva, L. K., Ul'yanova, M. V. (2009). Oral insulin preparations for the regulation of the glucose level in the blood. Biomeditsinskaya khimiya, 55(2), 195-200.
This paper is also available as the English translation: 10.1134/S1990750810010154
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