Decline of antibodies to hepatitis c virus during antiviral therapy

Nikolaeva L.I.1 , Makashova V.V.2, Petrova E.V.3, Shipulin G.A.2, Samokhvalov E.I.1, Lvov D.K.1

1. D.I. Ivanovsky Institute of Virology, Russian Academy of Medical sciences
2. Central Research Institute of Epidemiology
3. 2d Hospital of Infection Diseases
Section: Experimental/Clinical Study
PubMed Id: 19507344
Year: 2009  Volume: 55  Issue: 2  Pages: 201-212
The goal of this study was to investigate interrelationship between changes in anti-hepatitis C virus antibody and response to antiviral therapy. The comparative quantitative analysis of antibodies to individual structural and nonstructural viral proteins was done during two years in three patient groups: initial responders, non-responders and a reference group (without therapy). All patients in the treated groups exhibited decrease in the analyzed antibodies to HCV proteins, but with different patterns. The first statistically significant difference in the decrease of virus-specific antibody between initial responders and non-responders was observed within the first three months of therapy beginning. Some treated patients demonstrated decrease in antibody levels to HCV proteins after the end of therapy.
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Keywords: hepatitis C, antiviral therapy, antibody

Nikolaeva, L. I., Makashova, V. V., Petrova, E. V., Shipulin, G. A., Samokhvalov, E. I., Lvov, D. K. (2009). Decline of antibodies to hepatitis c virus during antiviral therapy. Biomeditsinskaya Khimiya, 55(2), 201-212.
This paper is also available as the English translation: 10.1134/S1990750809020127
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