1. D.I. Ivanovsky Institute of Virology, Russian Academy of Medical sciences 2. Central Research Institute of Epidemiology 3. 2d Hospital of Infection Diseases
The goal of this study was to investigate interrelationship between changes in anti-hepatitis C virus antibody and response to antiviral therapy. The comparative quantitative analysis of antibodies to individual structural and nonstructural viral proteins was done during two years in three patient groups: initial responders, non-responders and a reference group (without therapy). All patients in the treated groups exhibited decrease in the analyzed antibodies to HCV proteins, but with different patterns. The first statistically significant difference in the decrease of virus-specific antibody between initial responders and non-responders was observed within the first three months of therapy beginning. Some treated patients demonstrated decrease in antibody levels to HCV proteins after the end of therapy.
Nikolaeva L.I., Makashova V.V., Petrova E.V., Shipulin G.A., Samokhvalov E.I., Lvov D.K. (2009) Decline of antibodies to hepatitis c virus during antiviral therapy. Biomeditsinskaya Khimiya, 55(2), 201-212.
Nikolaeva L.I. et al. Decline of antibodies to hepatitis c virus during antiviral therapy // Biomeditsinskaya Khimiya. - 2009. - V. 55. -N 2. - P. 201-212.
Nikolaeva L.I. et al., "Decline of antibodies to hepatitis c virus during antiviral therapy." Biomeditsinskaya Khimiya 55.2 (2009): 201-212.
Nikolaeva, L. I., Makashova, V. V., Petrova, E. V., Shipulin, G. A., Samokhvalov, E. I., Lvov, D. K. (2009). Decline of antibodies to hepatitis c virus during antiviral therapy. Biomeditsinskaya Khimiya, 55(2), 201-212.
Mikkelsen M., Bukh J. (2007) Curr. Infect. Dis. Rep., 9, 94-101. Scholar google search
Robbins P.W., Myers G., Howard C., Brettin T., Bukh J., Gasschen B., Gojobori T., Maertens G., Maertens G., Mizokami M., Nainan O., Netesov S., Nishioka K., Shini T., Simmonds P., Smith D., Stuyver L., Weiner A. (1998) Arch. Virol., 143, 2493-2503. Scholar google search
Simmonds P., Holmes E.C., Cha S.-W., McOmish F., Irvine B., Beall E., Yap P.L., Kolberg J., Urdea M.S. (1993) J. Gen. Virol., 74, 2391-2399. Scholar google search
Brillanti S., Masci C., Ricci P., Miglioli M., Barbara L. (1992) Hepatology, 15, 998-1001. Scholar google search
Quiroga J.A., van Binsbergen J., Wang C.Y., Paardo M., Navas S., Trines C., Herrero M., Carreno V. (1995) Hepatology, 22, 1635-1640. Scholar google search
Pawlotsky J.M., Roudot-Thoraval F., Bastie A., Darthuy F., Remire J., Metreau J.M., Zafrani E.S., Duval J., Dhumeaux D. (1996) J. Infect. Dis., 174, 1-7. Scholar google search
Yuki N., Hayashi N., Hagiwara H., Naito M., Kasahara A., Fusamoto H., Kamada T. (1994) J. Hepatol., 20, 421-425. Scholar google search
Kao J.H., Lai M.Y., Chen P.J., Chen D.S. (1997) J. Formos. Med. Assoc., 96, 825-828. Scholar google search
Yuki N., Hayashi N., Mita E., Hagiwara H., Oshita M., Ohkawa K., Katayama K., Fusamoto H., Katamada T. (1995) J. Med. Virol., 45, 162-167. Scholar google search
Yoshimura E., Hayashi J., Kishihara Y., Yamaji K., Kinukawa N., Kashiwagi S. (1996) Dig. Dis. Sci., 41, 155-160. Scholar google search
Sakugawa H., Nakasone H., Nakayoshi T., Kawakami Y., Kinjo F., Saito A., Nakayoshi T., Yamashira A. (1998) Microbiol. Immunol., 42, 299-303. Scholar google search
Frangeul J.L., Cresta P., Perrin M., Duverlie G., Khorsi H., Musset L., Opolon P., Huraux J.M., Lunel F. (1998) Hepatology, 28, 538-543. Scholar google search
Desombere I., Van Vlierberghe H., Weiland O., Hultgren C., Sallberg M., Quiroga J., Carreno V., Leroux-Roels G. (2007) J. Med. Virol., 79, 701-713. Scholar google search
Tabone M., Secreto P., Marini C., Bonardi R., Boero M., Taraglio S., Ercole E., Sallio B.F., Pera A. (1997) Eur. J. Gastroenterol. Hepatol., 9, 287-291. Scholar google search
Sobolev B.N., Poroikov V.V., Olenina L.V., Kolesanova E.F., Archakov A.I. (2002) J. Viral. Hepat., 7, 368-374. Scholar google search
Urushihara A., Sodeyama T., Matsumoto A., Tanaka E. (1994) J. Med. Virol., 42, 348-356. Scholar google search
Park Y.M., Byung B.H., Choi J.Y., Bae S.H., Kim B.S., So H.-S., Ryu W.S. (1999) J. Korean Med. Sci., 14, 165-170. Scholar google search
Farci P., Shimoda A., Wong D., Cabezon T., De Gioannis D., Strazzera A., Shimizu Y., Shapiro M., Alter H.J., Purcell R. (1996) Proc. Natl. Acad. Sci. USA, 96, 15394-15399. Scholar google search
Owsianka A., Tarr A.W., Juttla V.S., Lavillette D., Bartosch B., Cosset F.-L., Ball J.K., Patel A.H. (2005) J. Virol., 79, 11095-11104. Scholar google search
Strader D.B., Wright T., Thomas D.L., Seeff L.B. (2004) Hepatology, 39, 1147-1171. Scholar google search
