Application of blood plasma metabolites fingerprinting for the diagnostic of the 2nd stage of prostate cancer has been investigated. The diagnostic sensitivity (95%), specificity (96,7%) and accuracy (95,7%) of the metabolic fingerprinting were much higher then those for PSA test (35%, 83,3% and 51,7%, respectively) for the same patients. Area under the ROC-curve (0,994) suggests that the proposed approach is effective and can be used for clinical applications.
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Keywords: metabolomics, metabolic fingerprinting, mass spectrometry, prostate cancer
Citation:
Lokhov P.G., Dashtiev M.I., Bondartscov L.V., Lisitsa A.V., Moshkovskii S.A., Archakov A.I. (2009) Metabolic fingerprinting of blood plasma for patients with prostate cancer. Biomeditsinskaya Khimiya, 55(3), 247-254.
Lokhov P.G. et al. Metabolic fingerprinting of blood plasma for patients with prostate cancer // Biomeditsinskaya Khimiya. - 2009. - V. 55. -N 3. - P. 247-254.
Lokhov P.G. et al., "Metabolic fingerprinting of blood plasma for patients with prostate cancer." Biomeditsinskaya Khimiya 55.3 (2009): 247-254.
Lokhov, P. G., Dashtiev, M. I., Bondartscov, L. V., Lisitsa, A. V., Moshkovskii, S. A., Archakov, A. I. (2009). Metabolic fingerprinting of blood plasma for patients with prostate cancer. Biomeditsinskaya Khimiya, 55(3), 247-254.
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