Photodynamic therapy (PDT) is a minimally invasive and promising new modality to combat cancer. The method is based on selective accumulation of sensitizers within tumor cells. The high degree of selectivity offered by this modality has been applied for fluorescent diagnostic of cancer. Photosensitization of a tissue-localized sensitizer generates cytotoxic reactive oxygen species as a result the selective destruction of tumor may be achieved. The PDT's major advantages compared to traditional methods of cancer treatment are better selectivity, low skin and general toxicity. This review highlights first and second generations of sensitizers, their photosensitizing abilities and drawbacks. Future developments in PDT will certainly include the discovery of new photosensitizers and a broadening of the applications of the treatment by various means.
Download PDF:
Keywords: photodynamic therapy, cancer, photosensitizers, methods of treatment, fluorescence diagnostics
Citation:
Kudinova N.V., Berezov T.T. (2009) Photodynamic therapy: search for ideal photosensitizer. Biomeditsinskaya Khimiya, 55(5), 558-569.
Kudinova N.V. et al. Photodynamic therapy: search for ideal photosensitizer // Biomeditsinskaya Khimiya. - 2009. - V. 55. -N 5. - P. 558-569.
Kudinova N.V. et al., "Photodynamic therapy: search for ideal photosensitizer." Biomeditsinskaya Khimiya 55.5 (2009): 558-569.
Kudinova, N. V., Berezov, T. T. (2009). Photodynamic therapy: search for ideal photosensitizer. Biomeditsinskaya Khimiya, 55(5), 558-569.
Moan J., Berg E., Kvam A., Western A, Malik Z., Ruck A., Schneckenburger W.A. (1989) in: Photosensitizing Compounds: Their Chemistry, Biology, and Clinical Use, рp. 95-107, Wiley, Chichester, UK. Scholar google search
Gibson S., VanDerMeid K., Murant R., Hilf R. (1990) Cancer Res, 50, 7236-7241. Scholar google search
Henderson B., Bellnier D. (1989) In Photosensitizing Compounds: Their Chemistry, Biology, Clinical Use, Wiley, Chichester, UK, pp. 121-125. Scholar google search
Brandis A., Mazor O., Neumark E., Salomon Y., Scherz A. (2005) Photochem. Photobiol., 81(4), 983-994. Scholar google search
Koudinova N., Pinthus J. Brandis A., Brenner O., Scherz A. Salomon Y. (2003) Int. J. Cancer, 104, 782-789. Scholar google search
Soncin M.J. (1998) Photochem. Photobiol. B Biol., 42, 202-206. Scholar google search
Brasseur N., Nguyen T., Langlois R. (1994) J. Med. Chem., 37, 415-420. Scholar google search
Kennedy J., Pottier R. (1992) J. Photochem. Photobiol. B Biol.14, 275-292. Scholar google search
Calzavara-Pinton P., Venturini M., Sala R., Zane C. (2008) Br. J. Dermatol., 159(1), 137-144. Scholar google search
Klein A., Babilas P. Karrer S., Landthaler M. (2008) J. Dtsch. Dermatol. Ges., 4, 15-18. Scholar google search
Патока Е., Харнас С., Рыбин В., Каримова Н. (2002) Тезисы научно-практической конференции "Отечественные противоопухолевые препараты", с.136. Scholar google search
Вакуловская Е., Губин А., Поддубный Б., Вакурова Е. (2005) Рос. биотерапев. журн., 1(4), 32-37 . Scholar google search
Поддубный Б., Губин А., Шолохов В., Вакурова Е., Блюменберг К. (2005) Сов. онкология, 7(3), 21-26. Scholar google search
Mew D., Wat C.K., Towers G.H., Levy J.G. (1983) J. Immunol., 130, 1473-1477. Scholar google search
Goff B.A., Bamberg M., Hasan T. (1991) Cancer Res., 51, 4762-4767. Scholar google search
